In a randomized, multi-center, placebo controlled study, 107 patients with metabolic syndrome with non alcoholic fatty liver disease were given either placebo or 650 mg of Citrus Flavanone-O-Glycosides or placebo twice a day for 120 days.
The Citrus group showed significant reduction of fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, and then the increase of HDL cholesterol. Hepatorenal index was significantly reduced by 46%, accompanied by the reduction of hepatic ultrosonographic patterns of steatosis by 99%. This suggests Citrus Flavanone-Glycosides help improve both liverfunction and inflammation as confirmed by reduction of TNF−α and CRP.™
64 subjects (32 men and 32 women) with moderate stress level were randomized to receive 200 mg/day of Eurycoma Longifolia extract or placebo for 4 weeks. At the end of treatment, Eurycoma group showed significant improvements for Tension (−11%), Anger (−12%), and Confusion (−15%) compared to placebo. Stress hormone profile (salivary cortisol and testosterone) was significantly improved by Eurycoma, with reduced cortisol (−16%) and increased testosterone (+37%). Eurycoma is effectively in restoring stress hormone profile and improving psychological mood state, shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training.
50 moderately overweight men and women were recruited to participate in a 6-week program of stress management, nutrition intervention, exercise, and CitruSlim® supplementation. 40 were given 200mg of CitruSlim®, and 10 were given placebo. All subjects followed a moderate calorie-restricted diet based on resting metabolic rate (RMR), plus a moderate exercise program (5 d/wk including aerobic & strength training), and stress management techniques (daily). At the end of the 6 weeks trial, the CitruSlim® group had a 95% completion rate, while the placebo group had an 80% completion rate. Suggesting that the program was easy to follow and not overly restrictive. This is much higher compare to other diet programs, such as 50% completion rate for Atkins and Pritikin diet, 65% completion rate for weight watcher and Zone diet. Participants in the CitruSlim® Group showed significant body weight loss of an average of 2.7kg. 2.4kg is in body fat loss, suggesting 87% of the total weight loss is body fat loss. On the other hand, participants in the placebo group do not show significant body weight loss (0.78kg) or body fat loss (0.55kg).
The Cortisol Testosterone ratio decreased significantly by 15% for the CitruSlim® group vs. a 7% increase for the placebo group. CitruSlim® promotes an anabolic state by maintaining normal low cortisol levels and normal high testosterone levels. The higher testosterone levels also contribute to higher energy levels and reduced fatigue, leading to a higher completion rate for the weight loss program.
At the end of the 6 week trial, the CitruSlim® group showed significant reduction of total cholesterol by 17% and LDL by 15% vs. no change for the placebo group.
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