In this study, we investigated the effect of a fish protein hydrolysate, Slimpro®, obtained from blue whiting (Micromesistius poutassou) muscle by enzymatic hydrolysis, on body composition and in the stimulation of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) secretions. We evaluated the efficiency, safety and dose-effect relationship of the fish protein hydrolysate, SLIMPRO® in 120 slightly overweight subjects. The study was controlled using a placebo product. The primary objective was to evaluate the product effect in the decrease of both body weight and fat mass. Complementary parameters related to the slimming process were also evaluated: decrease of extracellular water; decrease of waist, hip and thigh measurements; evolution of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) levels in the blood.
Treated subjects reported an improvement of body weight (particularly fat mass) composition and an increased concentration in the blood of both CCK and GLP-1. No differences were found between the 1.4 and 2.8 g FPH doses, indicating a plateau effect starting from 1.4 g FPH.